An e-Business Model Ontology for Modeling e-Business

After explaining why business executives and academics should consider thinking about a rigorous approach to e-business models, we introduce a new e-Business Model Ontology. Using the concept of business models can help companies understand, communicate and share, change, measure, simulate and learn more about the different aspects of e-business in their firm. The generic e-Business Model Ontology (a rigorous definition of the e-business issues and their interdependencies in a company’s business model), which we outline in this paper is the foundation for the development of various useful tools for e-business management and IS Requirements Engineering. The e-Business Model Ontology is based on an extensive literature review and describes the logic of a “business system” for creating value in the Internet era. It is composed of four main pillars, which are Product Innovation, Infrastructure Management, Customer Relationship and Financial Aspects. These elements are then further decomposed.e-business models, ontology, e-business, strategy

The Business Model Handbook for Developing Countries

The Business Model Handbook (BMH) for developing countries is a proposition for a tool that has the goal to help Small and Medium Sized Enterprises (SME) and local entrepreneurs to design business models that use Information and Communication Technologies (ICT) and particularly the Internet in the context of developing economies. It shall help to develop the urgently needed critical mass of knowledge workers, technology users, and motivated entrepreneurs in order to deploy ICT in businesses of developing countries. Never before the Internet it has been as easy to share and transfer knowledge in such an efficient and global way. The objective of this Paper is twofold. First it proposes a theoretical business model framework (BMF) which shall allow SMEs, but also motivated local entrepreneurs in developing countries to understand the most relevant business issues in the Information Society. The BMF gives special attention to the opportunities that arise out of the use of Information Technology (IT) and particularly the use of the Internet for businesses in emerging economies (i.e. e-commerce). The second objective, which is the introduction of the Business Model Handbook for Developing Countries, shall allow an efficient knowledge transfer of the concepts developed and illustrated in the BMF. Therefore, the BMH should be deployed as a Web based tool, which allows Users to navigate through the concepts and the corresponding real world examples (case studies) and easily learn about business opportunities.developing countries, e-business

Modeling e-Business with eBML

In this paper we demonstrate that modeling e-business strategies is important in a time where the first e-business disillusionment has taken place. The objective of this Paper is twofold. First we propose a theoretical e-business model framework (eBMF) for aligning e-business initiatives and projects. This framework rep-resents an ontology, which will allow firms to develop a sound e-business model, in an environment that is amongst other things characterized by new forms of network organizations. Second we show why the eX-tensible Markup Language (XML) is an adequate technology for describing this theoretical framework in a formal way.xml, e-business models, e-business

Investigating the Use of the Business Model Concept through Interviews

The term business model is widely used and is increasingly gaining importance as a business concept and management tool, particularly in e-business. Several authors propose the application of the business model concept in different domains, such as for e-business planning, IS alignment, visualization, innovation, e-business process design or improving communication between stakeholders. Yet, little has been said on the business world\u27s perception of the use of business models, which this paper attempts to investigate through semi-structured interviews with company executives and business consultants

Functional Integral Construction of the Thirring model: axioms verification and massless limit

We construct a QFT for the Thirring model for any value of the mass in a functional integral approach, by proving that a set of Grassmann integrals converges, as the cutoffs are removed and for a proper choice of the bare parameters, to a set of Schwinger functions verifying the Osterwalder-Schrader axioms. The corresponding Ward Identities have anomalies which are not linear in the coupling and which violate the anomaly non-renormalization property. Additional anomalies are present in the closed equation for the interacting propagator, obtained by combining a Schwinger-Dyson equation with Ward Identities.Comment: 55 pages, 9 figure

Response of the topological surface state to surface disorder in TlBiSe2_2

Through a combination of experimental techniques we show that the topmost layer of the topo- logical insulator TlBiSe$_2$ as prepared by cleavage is formed by irregularly shaped Tl islands at cryogenic temperatures and by mobile Tl atoms at room temperature. No trivial surface states are observed in photoemission at low temperatures, which suggests that these islands can not be re- garded as a clear surface termination. The topological surface state is, however, clearly resolved in photoemission experiments. This is interpreted as a direct evidence of its topological self-protection and shows the robust nature of the Dirac cone like surface state. Our results can also help explain the apparent mass acquisition in S-doped TlBiSe$_2$.Comment: 16 pages, 5 figure

Business Models in a New Digital Culture: The Open Long Tail Model

New business models are emerging in global markets. Quirky is producing new products designed and developed by the community and finally produced by the 3D printing technology. Google gives his glasses to different developers who build up their own applications. Kickstarter finds the funders by the use of the crowd, paying them back with the future products. Employees, funders, customers and partners do not play a stable role with the organization but revolve around it using different form of collaborations related to the organization’s needs. In this scenario business like Amazon find out their own achievement feeding up different customers’ needs

Wt1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium.

During development, the heart grows by addition of progenitor cells to the poles of the primordial heart tube. In the zebrafish, Wilms tumor 1 transcription factor a (wt1a) and b (wt1b) genes are expressed in the pericardium, at the venous pole of the heart. From this pericardial layer, the proepicardium emerges. Proepicardial cells are subsequently transferred to the myocardial surface and form the epicardium, covering the myocardium. We found that while wt1a and wt1b expression is maintained in proepicardial cells, it is downregulated in pericardial cells that contributes cardiomyocytes to the developing heart. Sustained wt1b expression in cardiomyocytes reduced chromatin accessibility of specific genomic loci. Strikingly, a subset of wt1a- and wt1b-expressing cardiomyocytes changed their cell-adhesion properties, delaminated from the myocardium and upregulated epicardial gene expression. Thus, wt1a and wt1b act as a break for cardiomyocyte differentiation, and ectopic wt1a and wt1b expression in cardiomyocytes can lead to their transdifferentiation into epicardial-like cells.NM has been funded by SNF grant 320030E-164245 and ERC Consolidator grant 2018 819717. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Benoît Zuber is supported by SNF grant 179520 and ERA-NET NEURON grant 185536. M.O. was supported by SNF grant PCEFP3_186993.S

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

Non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a human stem cell differentiation model, we identify two clusters of enhancers within the PRS-associated region that regulate SOX9 expression during a restricted window of facial progenitor development at distances up to 1.45 Mb. Enhancers within the 1.45 Mb cluster exhibit highly synergistic activity that is dependent on the Coordinator motif. Using mouse models, we demonstrate that PRS phenotypic specificity arises from the convergence of two mechanisms: confinement of Sox9 dosage perturbation to developing facial structures through context-specific enhancer activity and heightened sensitivity of the lower jaw to Sox9 expression reduction. Overall, we characterize the longest-range human enhancers involved in congenital malformations, directly demonstrate that PRS is an enhanceropathy, and illustrate how small changes in gene expression can lead to morphological variation